mpo inhibitor azm198 Search Results


mpo inhibitor azm198  (AstraZeneca ltd)
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AstraZeneca ltd mpo inhibitor azm198
(A) Experimental layout. Six-week-old MFS were fed either a control diet (N=9) or a MPO inhibitor <t>AZM198</t> containing diet (N=10) for six weeks. (B) Representative 2D echocardiographic image with diameter measurements at the position of the (C) aortic annulus, (D) sinus Valsalva, (E) sinotubular junction, and (F) aorta ascendens in twelve-week-old-MFS mice. Scale bar indicates 1 mm. (G) Representative images of van Gieson stained elastica in ascending aortic sections and average number of elastin breaks per 100 μm of elastic lamina (control N=9, MFS + AZM198 N=10). Scale bar indicates 50 μm. Data is presented as mean ± SEM. Statistical significance was determined by an unpaired t test.
Mpo Inhibitor Azm198, supplied by AstraZeneca ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/mpo+inhibitor+azm198/azm198/bio_rxiv__2022__11__24__517172-171-18-21
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mpo inhibitor azm198 - by Bioz Stars, 2026-10
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(A) Experimental layout. Six-week-old MFS were fed either a control diet (N=9) or a MPO inhibitor AZM198 containing diet (N=10) for six weeks. (B) Representative 2D echocardiographic image with diameter measurements at the position of the (C) aortic annulus, (D) sinus Valsalva, (E) sinotubular junction, and (F) aorta ascendens in twelve-week-old-MFS mice. Scale bar indicates 1 mm. (G) Representative images of van Gieson stained elastica in ascending aortic sections and average number of elastin breaks per 100 μm of elastic lamina (control N=9, MFS + AZM198 N=10). Scale bar indicates 50 μm. Data is presented as mean ± SEM. Statistical significance was determined by an unpaired t test.

Journal: bioRxiv

Article Title: Inhibition of myeloperoxidase attenuates thoracic aortic aneurysm formation in Marfan disease

doi: 10.1101/2022.11.24.517172

Figure Lengend Snippet: (A) Experimental layout. Six-week-old MFS were fed either a control diet (N=9) or a MPO inhibitor AZM198 containing diet (N=10) for six weeks. (B) Representative 2D echocardiographic image with diameter measurements at the position of the (C) aortic annulus, (D) sinus Valsalva, (E) sinotubular junction, and (F) aorta ascendens in twelve-week-old-MFS mice. Scale bar indicates 1 mm. (G) Representative images of van Gieson stained elastica in ascending aortic sections and average number of elastin breaks per 100 μm of elastic lamina (control N=9, MFS + AZM198 N=10). Scale bar indicates 50 μm. Data is presented as mean ± SEM. Statistical significance was determined by an unpaired t test.

Article Snippet: MFS mice and wildtype littermates were either fed a standard chow diet or standard chow supplemented with the MPO inhibitor AZM198 (AstraZeneca, Stockholm, Sweden; 1,146g/kg) ad libitum.

Techniques: Staining